Reviews & Meta-analyses
Systematic reviews
Systematic literature reviews (SLRs) ensure an exhaustive identification of all relevant information to answer your research question.
SLRs can be used to appraise a wide range of evidence, including efficacy, safety, quality of life, and economic costs and resource use, and are crucial for HTA submissions and shaping your market access strategy.
Our experienced and highly published review team design and conduct reviews using Cochrane ‘gold standard’ methodology and support you in the interpretation and application of the results.
Pragmatic reviews
Pragmatic reviews take a more targeted approach to identify the best available evidence when SLRs are not the most suitable option.
We tailor our pragmatic reviews to your specific needs and work closely with you throughout the process, from helping you determine the optimal research question through to understanding how the results inform your strategy.
Meta-analysis
Our systematic review and statistical team specialise in meta-analyses and indirect treatment comparisons which are a central requirement of most HTA submissions.
We carry out pairwise meta-analyses, network meta-analyses, single-arm comparisons, matching-adjusted indirect comparisons (MAIC), simulated treatment comparisons (STC) and meta-regressions.
Our robust and HTA-compliant statistical methods demonstrate the value of your product by assessing its relative effectiveness and safety to comparative treatments.
Evidence retrieval & literature search support
High quality and robust literature searching is the foundation of any well-conducted systematic review or large-scale project. We ensure our methods represent best evidence-based practice in information retrieval and we appreciate the importance of conducting timely and thorough searches, delivered in a systematic, rigorous, and reproducible manner.
By keeping up to date with developments in information retrieval, we can tailor our methods to suit your research requirements; from selecting appropriate study design filters, to peer reviewing search strategies and processes to ensure quality assurance. We fully document strategies and search methods, ensuring adherence to current reporting standards, such as PRISMA-S.
Due to our commitment to information retrieval of the highest standard and our many years of experience, we regularly devise and conduct rigorous and comprehensive literature searches for large scale projects, including systematic reviews, HTAs, economic evaluations, scoping reviews, national guidance, and guideline development.
We offer training and advice on any aspect of the search process, from planning a proposal, scoping the literature, undertaking systematic review searches, quality assuring the search methods, to documenting the processes to meet the reporting standards recommended by UK NICE, Cochrane and the Centre for Reviews and Dissemination. We can tailor training materials and course content to your specific organisational needs.